PhD Studentships in the Biomolecular Electronics Research Laboratory, National University of Ireland, Galway, Ireland

Postgraduate Studentships in Chemistry
National University of Ireland, Galway

Commencing September/October 2009

Biomolecular Electronics Research Laboratory

Several fully-funded post-graduate Ph.D. studentships in the Biomolecular Electronics Research Laboratory are available, funded under collaborative research awards by the ERA - Chemistry initiative, the EU FP7 programme, and a Charles Parsons Energy Research Award.

Programme Topics:

1. Preparation, characterization and evaluation of integrated bioelectrocatalytic systems (enzyme-based) for sensor and energy conversion

2. Bioelectrocatalytic (enzyme and microbial) systems for electricity generation

An honours undergraduate qualification in a scientific or engineering discipline, with a significant training in Chemistry is an essential qualification for applicants. A background in enzyme biochemistry, or microbial ecology is an advantage for intending applicants for topics 1 and 2, respectively.

Applicants should submit their CV, detailing relevant experience, a personal statement, outlining reasons for their interest in the post, and the name of three references to:

Donal.leech[ at ]nuigalway.ie

For further information contact:

Dr. Dónal leech
Biomolecular Electronics Research Laboratory
School of Chemistry
National University of Ireland, Galway

Ph: +353 91 493563
E-mail: Donal.leech[ at ]nuigalway.ie

UK: PhD Studentship in the Computational Investigation of Drug Resistant Mutations in the Kinases, University of Southampton

PhD Studentship in the Computational Investigation of Drug Resistant Mutations in the Kinases, University of Southampton, UK

Academic Supervisor: Professor Jonathan W. Essex, School of Chemistry, University of Southampton.
Industrial Supervisor: Dr Richard A Ward, AstraZeneca, Alderley Park, Macclesfied.

Kinase proteins are intimately involved in cell signalling, and in many cases mutations to these proteins are involved in the development of cancers. A number of small-molecule drugs have been developed to target these proteins, most notably gleevec, which binds to the BCR-ABL kinase and is used as a treatment for chronic myelogenous leukemia, and iressa, which binds to the epidermal growth factor receptor’s (EGFR) tyrosine kinase domain and is used to treat non-small cell lung cancer. However, as is the case for bacteria and viruses, the tumour proteins can mutate and thereby develop resistance to these drugs. The mechanisms by which these mutations confer drug resistance are unclear, and are likely to depend on the particular mutation involved. Clearly, however, if we are able to understand these mechanisms, we are then in a position to design novel inhibitors which are unaffected by these mutations.

In this studentship, you will address the issue of how mutations of EGFR confer drug resistance to kinase inhibitors by using a range of simulation techniques, including docking and scoring, fast free energy calculations, and more accurate rigorous free energy methods. Methods to calculate the relative free energies of different protein conformations will also be used. This studentship is funded by the EPSRC and AstraZeneca (AZ), and will be supported by direct access to relevant experimental data available through AZ. The project will be supervised by Prof Jonathan Essex at the University of Southampton, together with a senior scientist from AZ. You will be joining an established research team working in the area of applying and developing computer simulation methods to biological problems.

Applicants
should have, or expect to receive shortly, a good degree in chemistry, physics, biochemistry, or a relevant discipline, and a keen interest in molecular modelling. Please contact Dr Richard A Ward (richard.a.ward[ at ]astrazeneca.com) for enquiries related to this project and for further information
regarding the nature of this industrially-sponsored studentship.