The Georg-Speyer-Haus in Frankfurt am Main, Germany is an academic research institute of great tradition in biomedical sciences. The institute maintains the status of an independent foundation, and is supported by the German Federal Ministry of Health and the Ministry for Sciences and Arts of the State of Hessen. The Georg-Speyer-Haus is dedicated to basic and translational research in the fields of cancer and infectious diseases, and cooperates closely with the University of Frankfurt.
2 PhD positions at the Georg-Speyer-Haus in Frankfurt am Main (Germany)
We are seeking highly motivated PhD students with interest in molecular, genomic and cellular cancer research.
Our research team is interested in tumour suppressor mechanisms of the p53-protein family in the post-genomic and epigenetic era. We are applying modern molecular and cellular techniques to study the tumour-suppressor mechanisms of the p53-family in healthy as well as cancerous cells.
The group is hosted at the Georg-Speyer-Haus in Frankfurt am Main, a high-ranking cancer research institute. We offer an innovative and scientifically stimulating surrounding, a well-equipped lab as well as an ambitious, friendly and cooperative team. The position is available initially for a period of 2 years (PhD); salary is according to German BAT IIa (50%, PhD).
Applicants must hold a diploma/master degree in biology, biochemistry, human biology or a related field. Previous experience in molecular biology is appreciated.
Please send your complete application (CV, letter of motivation, name and address of two referees) via email to: m.lohrum[ at ]ncmls.ru.nl
Printed applications should be sent to: Christiane Strack, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, D-60596 Frankfurt/Main, Tel: 0049-69-63395-104.
www.georg-speyer-haus.de
The Radboud University Nijmegen Medical Centre is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.
Tuesday, June 30, 2009
UK: PhD Studentships in Molecular Dynamics and/or Monte-Carlo Simulations of an Ion-channel, University of Warwick
Warwick School of Engineering and Centre for Scientific Computations
PhD studentship
Stipend: £13,290 plus home tuition fees (£3400)
Commencing 1 October 2009 for 3,5 years
A PhD studentship is available for developing molecular dynamics and/or Monte-Carlo simulations of an ion-channel, explicitly including a relatively small patch of surrounding membrane and exterior water. The work will lead to a PhD in Engineering supervised by Dr Igor Khovanov, but will involve close collaboration with the departments of Physics (Prof M. P. Allen) and Chemistry (Prof P. M. Rodger) through the Centre for Scientific Computing. The successful applicant will have the opportunity to get involved with the state-of-the-art computational techniques, in particular molecular dynamics, as well as with high-performance parallel computing. The work involves close collaboration with Lancaster University and Rush Medical Center (Chicago), as well as the analysis of experimental data from Oxford, Rush, Groningen, and Chapel Hill. There will be opportunities for travel to conferences and between the participating centres.
The studentship is a part of joint Lancaster-Warwick project “Nonlinear dynamics of selectivity, conductivity, and gating in biological ion channels” aimed at cracking the enduring problem of how ions permeate through ion channels in biological membranes. The importance of progress in this area can hardly be over-estimated, given its centrality to physiological processes at the cellular level and that that most drugs are targeted directly or indirectly at ion channels. The investigations bring new ideas from non-equilibrium physics to focus on long-standing problems that are of central importance in biology.
This studentship has been funded by EPSRC. The studentship is available to UK, EU and International candidates. However, funds are only available to cover UK/EU Tuition Fees. International candidates (outside EU) would be required to pay the difference between UK/EU Tuition Fees and International Tuition Fees.
You must have a good honours degree in Engineering, Chemistry, Mathematics, Physics, Computer Science or similar. You should have a strong interest in computer simulations and program development.
Informal enquires may be made to Dr Igor Khovanov, e-mail: i.khovanov[ at ]warwick.ac.uk
PhD studentship
Stipend: £13,290 plus home tuition fees (£3400)
Commencing 1 October 2009 for 3,5 years
A PhD studentship is available for developing molecular dynamics and/or Monte-Carlo simulations of an ion-channel, explicitly including a relatively small patch of surrounding membrane and exterior water. The work will lead to a PhD in Engineering supervised by Dr Igor Khovanov, but will involve close collaboration with the departments of Physics (Prof M. P. Allen) and Chemistry (Prof P. M. Rodger) through the Centre for Scientific Computing. The successful applicant will have the opportunity to get involved with the state-of-the-art computational techniques, in particular molecular dynamics, as well as with high-performance parallel computing. The work involves close collaboration with Lancaster University and Rush Medical Center (Chicago), as well as the analysis of experimental data from Oxford, Rush, Groningen, and Chapel Hill. There will be opportunities for travel to conferences and between the participating centres.
The studentship is a part of joint Lancaster-Warwick project “Nonlinear dynamics of selectivity, conductivity, and gating in biological ion channels” aimed at cracking the enduring problem of how ions permeate through ion channels in biological membranes. The importance of progress in this area can hardly be over-estimated, given its centrality to physiological processes at the cellular level and that that most drugs are targeted directly or indirectly at ion channels. The investigations bring new ideas from non-equilibrium physics to focus on long-standing problems that are of central importance in biology.
This studentship has been funded by EPSRC. The studentship is available to UK, EU and International candidates. However, funds are only available to cover UK/EU Tuition Fees. International candidates (outside EU) would be required to pay the difference between UK/EU Tuition Fees and International Tuition Fees.
You must have a good honours degree in Engineering, Chemistry, Mathematics, Physics, Computer Science or similar. You should have a strong interest in computer simulations and program development.
Informal enquires may be made to Dr Igor Khovanov, e-mail: i.khovanov[ at ]warwick.ac.uk
PhD Studentships in the Biomolecular Electronics Research Laboratory, National University of Ireland, Galway, Ireland
Postgraduate Studentships in Chemistry
National University of Ireland, Galway
Commencing September/October 2009
Biomolecular Electronics Research Laboratory
Several fully-funded post-graduate Ph.D. studentships in the Biomolecular Electronics Research Laboratory are available, funded under collaborative research awards by the ERA - Chemistry initiative, the EU FP7 programme, and a Charles Parsons Energy Research Award.
Programme Topics:
1. Preparation, characterization and evaluation of integrated bioelectrocatalytic systems (enzyme-based) for sensor and energy conversion
2. Bioelectrocatalytic (enzyme and microbial) systems for electricity generation
An honours undergraduate qualification in a scientific or engineering discipline, with a significant training in Chemistry is an essential qualification for applicants. A background in enzyme biochemistry, or microbial ecology is an advantage for intending applicants for topics 1 and 2, respectively.
Applicants should submit their CV, detailing relevant experience, a personal statement, outlining reasons for their interest in the post, and the name of three references to:
Donal.leech[ at ]nuigalway.ie
For further information contact:
Dr. Dónal leech
Biomolecular Electronics Research Laboratory
School of Chemistry
National University of Ireland, Galway
Ph: +353 91 493563
E-mail: Donal.leech[ at ]nuigalway.ie
National University of Ireland, Galway
Commencing September/October 2009
Biomolecular Electronics Research Laboratory
Several fully-funded post-graduate Ph.D. studentships in the Biomolecular Electronics Research Laboratory are available, funded under collaborative research awards by the ERA - Chemistry initiative, the EU FP7 programme, and a Charles Parsons Energy Research Award.
Programme Topics:
1. Preparation, characterization and evaluation of integrated bioelectrocatalytic systems (enzyme-based) for sensor and energy conversion
2. Bioelectrocatalytic (enzyme and microbial) systems for electricity generation
An honours undergraduate qualification in a scientific or engineering discipline, with a significant training in Chemistry is an essential qualification for applicants. A background in enzyme biochemistry, or microbial ecology is an advantage for intending applicants for topics 1 and 2, respectively.
Applicants should submit their CV, detailing relevant experience, a personal statement, outlining reasons for their interest in the post, and the name of three references to:
Donal.leech[ at ]nuigalway.ie
For further information contact:
Dr. Dónal leech
Biomolecular Electronics Research Laboratory
School of Chemistry
National University of Ireland, Galway
Ph: +353 91 493563
E-mail: Donal.leech[ at ]nuigalway.ie
Monday, June 29, 2009
UK: PhD Studentship in the Computational Investigation of Drug Resistant Mutations in the Kinases, University of Southampton
PhD Studentship in the Computational Investigation of Drug Resistant Mutations in the Kinases, University of Southampton, UK
Academic Supervisor: Professor Jonathan W. Essex, School of Chemistry, University of Southampton.
Industrial Supervisor: Dr Richard A Ward, AstraZeneca, Alderley Park, Macclesfied.
Kinase proteins are intimately involved in cell signalling, and in many cases mutations to these proteins are involved in the development of cancers. A number of small-molecule drugs have been developed to target these proteins, most notably gleevec, which binds to the BCR-ABL kinase and is used as a treatment for chronic myelogenous leukemia, and iressa, which binds to the epidermal growth factor receptor’s (EGFR) tyrosine kinase domain and is used to treat non-small cell lung cancer. However, as is the case for bacteria and viruses, the tumour proteins can mutate and thereby develop resistance to these drugs. The mechanisms by which these mutations confer drug resistance are unclear, and are likely to depend on the particular mutation involved. Clearly, however, if we are able to understand these mechanisms, we are then in a position to design novel inhibitors which are unaffected by these mutations.
In this studentship, you will address the issue of how mutations of EGFR confer drug resistance to kinase inhibitors by using a range of simulation techniques, including docking and scoring, fast free energy calculations, and more accurate rigorous free energy methods. Methods to calculate the relative free energies of different protein conformations will also be used. This studentship is funded by the EPSRC and AstraZeneca (AZ), and will be supported by direct access to relevant experimental data available through AZ. The project will be supervised by Prof Jonathan Essex at the University of Southampton, together with a senior scientist from AZ. You will be joining an established research team working in the area of applying and developing computer simulation methods to biological problems.
Applicants
should have, or expect to receive shortly, a good degree in chemistry, physics, biochemistry, or a relevant discipline, and a keen interest in molecular modelling. Please contact Dr Richard A Ward (richard.a.ward[ at ]astrazeneca.com) for enquiries related to this project and for further information
regarding the nature of this industrially-sponsored studentship.
Academic Supervisor: Professor Jonathan W. Essex, School of Chemistry, University of Southampton.
Industrial Supervisor: Dr Richard A Ward, AstraZeneca, Alderley Park, Macclesfied.
Kinase proteins are intimately involved in cell signalling, and in many cases mutations to these proteins are involved in the development of cancers. A number of small-molecule drugs have been developed to target these proteins, most notably gleevec, which binds to the BCR-ABL kinase and is used as a treatment for chronic myelogenous leukemia, and iressa, which binds to the epidermal growth factor receptor’s (EGFR) tyrosine kinase domain and is used to treat non-small cell lung cancer. However, as is the case for bacteria and viruses, the tumour proteins can mutate and thereby develop resistance to these drugs. The mechanisms by which these mutations confer drug resistance are unclear, and are likely to depend on the particular mutation involved. Clearly, however, if we are able to understand these mechanisms, we are then in a position to design novel inhibitors which are unaffected by these mutations.
In this studentship, you will address the issue of how mutations of EGFR confer drug resistance to kinase inhibitors by using a range of simulation techniques, including docking and scoring, fast free energy calculations, and more accurate rigorous free energy methods. Methods to calculate the relative free energies of different protein conformations will also be used. This studentship is funded by the EPSRC and AstraZeneca (AZ), and will be supported by direct access to relevant experimental data available through AZ. The project will be supervised by Prof Jonathan Essex at the University of Southampton, together with a senior scientist from AZ. You will be joining an established research team working in the area of applying and developing computer simulation methods to biological problems.
Applicants
should have, or expect to receive shortly, a good degree in chemistry, physics, biochemistry, or a relevant discipline, and a keen interest in molecular modelling. Please contact Dr Richard A Ward (richard.a.ward[ at ]astrazeneca.com) for enquiries related to this project and for further information
regarding the nature of this industrially-sponsored studentship.
UK: ESRC Collaborative Research Studentship, University of Edinburgh
Interventions to Promote Science Engagement: Reach and Impact
An ESRC Collaborative Research Studentship, offered by the Institute for the Study of Science, Technology and Innovation (ISSTI), University of Edinburgh, and The Scottish Government, Office of the Chief Researcher
Applicants are invited for an ESRC studentship starting September 2009. The normal ESRC grant applies (full fees and maintenance), with an additional supplement of £2000 p.a. The studentship follows a 1+3 format: one year of Masters research training and three years on the PhD programme. Please note that part-time studentships are not available.
All UK citizens are eligible to apply, plus EU citizens who satisfy ESRC residential requirements. Applicants must have a good honours degree. Candidates apply (see link below) via the Graduate School in Social and Political Science for the doctoral programme in Science and Technology Studies.
The studentship is attached to a collaborative project between the University of Edinburgh and The Scottish Government. The broad aim of this project is to provide insights into how best to promote science engagement in Scotland. Science engagement (SE) is understood to encompass activities seeking to increase public interest and participation in science and technology and related social and ethical issues, with different stakeholders having often differing agendas. By auditing existing SE activities, and conducting supplementary qualitative research with potential and actual audiences, the project seeks to establish the reach and impact of these activities, recognizing that the diverse publics may have quite different perspective on and experiences of them.
The successful candidate will join a thriving community of staff and students doing related research in ISSTI, and receive highly rated training through the Graduate School in Social and Political Science. They will also have the benefit of Scottish Government activities aimed at familiarising collaborative students with the policy world and building their skills in knowledge transfer. The project will be undertaken in cooperation with the Edinburgh Beltane, one of the six UK Beacons for Public Engagement.
Candidates should contact:
Dr Wendy Faulkner
w.faulkner[ at ]ed.ac.uk
0131 650 4069
to discuss their application. Applications are due by 6 July 2009.
Further information, please visit this page.
The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.
An ESRC Collaborative Research Studentship, offered by the Institute for the Study of Science, Technology and Innovation (ISSTI), University of Edinburgh, and The Scottish Government, Office of the Chief Researcher
Applicants are invited for an ESRC studentship starting September 2009. The normal ESRC grant applies (full fees and maintenance), with an additional supplement of £2000 p.a. The studentship follows a 1+3 format: one year of Masters research training and three years on the PhD programme. Please note that part-time studentships are not available.
All UK citizens are eligible to apply, plus EU citizens who satisfy ESRC residential requirements. Applicants must have a good honours degree. Candidates apply (see link below) via the Graduate School in Social and Political Science for the doctoral programme in Science and Technology Studies.
The studentship is attached to a collaborative project between the University of Edinburgh and The Scottish Government. The broad aim of this project is to provide insights into how best to promote science engagement in Scotland. Science engagement (SE) is understood to encompass activities seeking to increase public interest and participation in science and technology and related social and ethical issues, with different stakeholders having often differing agendas. By auditing existing SE activities, and conducting supplementary qualitative research with potential and actual audiences, the project seeks to establish the reach and impact of these activities, recognizing that the diverse publics may have quite different perspective on and experiences of them.
The successful candidate will join a thriving community of staff and students doing related research in ISSTI, and receive highly rated training through the Graduate School in Social and Political Science. They will also have the benefit of Scottish Government activities aimed at familiarising collaborative students with the policy world and building their skills in knowledge transfer. The project will be undertaken in cooperation with the Edinburgh Beltane, one of the six UK Beacons for Public Engagement.
Candidates should contact:
Dr Wendy Faulkner
w.faulkner[ at ]ed.ac.uk
0131 650 4069
to discuss their application. Applications are due by 6 July 2009.
Further information, please visit this page.
The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.
Germany: PhD Student Position, Modelling and Simulation of TNF-Receptor Clustering, University Stuttgart
PhD student position for the project Modelling and Simulation of TNF-Receptor Clustering, University Stuttgart, Cluster of Excellence in Simulation Technology, Germany
High-level PhD Positions at the Cluster of Excellence SimTech
Stuttgart Research Centre for Simulation Technology, Universität Stuttgart
Universität Stuttgart with its 20,000 students and 7,000 employees is one of the leading European Research Universities with a main focus on engineering and natural sciences. Universität Stuttgart is committed to excellent basic and applied research and interdisciplinary academic education. The excellence initiative of the German state and federal governments has approved the funding of the Cluster of Excellence EXC 310 Simulation Technology (SimTech) at Universität Stuttgart (www.simtech.uni-stuttgart.de). In this context, the newly established Stuttgart Research Centre for Simulation Technology (SRC SimTech) is asking for applications for scientists at the PhD level to pursue research in future-orientated research fields.
PhD student position for the project Modelling and Simulation of TNF-Receptor Clustering
The PhD student is supposed to work on a project aiming to investigate the first steps in Tumor Necrosis Factor (TNF) induced signal transduction. Thereby the focus is on the onset of ligand/receptor interaction and subsequent formation of signal clusters on the cell membrane which initiate intracellular signals eventually leading to cell death. Mathematical models have to be developed in order to describe the relevant mechanisms involved in this process. Enhanced knowledge is expected to be aquired from the mathematical analysis and numerical simulations of these models, leading to a better understanding of the constraints regulating the differential behavior of the two identified TNF receptors when binding the ligand TNF.
Applicants with a university degree (diploma or masters with very good results) in mathematics are invited. The successful candidate should have a strong background in stochastic processes, dynamical systems, partial differential equations, and numerical methods for the latter, as well as good programming skills in Matlab/C/C++. He/she should be interested in interdisciplinary research and collaboration with our biologist partners.
Applications with the usual documents (CV, degree certificates, references, publication list, letter of motivation) should be sent to Dr. Christina Surulescu (christina.surulescu[ at ]mathematik.uni-stuttgart.de) Institute of Applied Analysis and Numerical Simulations, Pfaffenwaldring 57, 70569 Stuttgart, Germany.
All positions with the designated salary bracket TV-L 13 have a limited tenure of three years with a possible extension.
The PhDs are expected to participate actively in the SimTech Teaching Programmes and Industry Transfer Concepts.
Universität Stuttgart wishes to increase the proportion of female academic staff and, for this reason, especially welcomes applications from women. Severely challenged persons will be given preference in case of equal qualifications.
For further positions and information please see: http://www.simtech.uni-stuttgart.de
High-level PhD Positions at the Cluster of Excellence SimTech
Stuttgart Research Centre for Simulation Technology, Universität Stuttgart
Universität Stuttgart with its 20,000 students and 7,000 employees is one of the leading European Research Universities with a main focus on engineering and natural sciences. Universität Stuttgart is committed to excellent basic and applied research and interdisciplinary academic education. The excellence initiative of the German state and federal governments has approved the funding of the Cluster of Excellence EXC 310 Simulation Technology (SimTech) at Universität Stuttgart (www.simtech.uni-stuttgart.de). In this context, the newly established Stuttgart Research Centre for Simulation Technology (SRC SimTech) is asking for applications for scientists at the PhD level to pursue research in future-orientated research fields.
PhD student position for the project Modelling and Simulation of TNF-Receptor Clustering
The PhD student is supposed to work on a project aiming to investigate the first steps in Tumor Necrosis Factor (TNF) induced signal transduction. Thereby the focus is on the onset of ligand/receptor interaction and subsequent formation of signal clusters on the cell membrane which initiate intracellular signals eventually leading to cell death. Mathematical models have to be developed in order to describe the relevant mechanisms involved in this process. Enhanced knowledge is expected to be aquired from the mathematical analysis and numerical simulations of these models, leading to a better understanding of the constraints regulating the differential behavior of the two identified TNF receptors when binding the ligand TNF.
Applicants with a university degree (diploma or masters with very good results) in mathematics are invited. The successful candidate should have a strong background in stochastic processes, dynamical systems, partial differential equations, and numerical methods for the latter, as well as good programming skills in Matlab/C/C++. He/she should be interested in interdisciplinary research and collaboration with our biologist partners.
Applications with the usual documents (CV, degree certificates, references, publication list, letter of motivation) should be sent to Dr. Christina Surulescu (christina.surulescu[ at ]mathematik.uni-stuttgart.de) Institute of Applied Analysis and Numerical Simulations, Pfaffenwaldring 57, 70569 Stuttgart, Germany.
All positions with the designated salary bracket TV-L 13 have a limited tenure of three years with a possible extension.
The PhDs are expected to participate actively in the SimTech Teaching Programmes and Industry Transfer Concepts.
Universität Stuttgart wishes to increase the proportion of female academic staff and, for this reason, especially welcomes applications from women. Severely challenged persons will be given preference in case of equal qualifications.
For further positions and information please see: http://www.simtech.uni-stuttgart.de
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